推出

推出

ผลลัพธ์ (ไทย) 1:

ปล่อย

ผลลัพธ์ (ไทย) 2:

ppress viral replication and dissemination at an early stage.
For SARS-CoV and MERS-CoV, the response to viral infection by type I IFN is suppressed. Both coronaviruses employ multiple strategies to interfere with the signaling leading
to type I IFN production and/or the signaling downstream of
IFNAR. This dampening strategy is closely associated with the
disease severity.29 At the step of type I IFN induction, SARSCoV interferes with the signaling downstream of RNA sensors directly or indirectly such as ubiquitination and degradation of RNA sensor adaptor molecules MAVS and TRAF3/6
and inhibiting IRF3 nuclear translocation.30 MERS-CoV also
utilizes some of these strategies with additional mechanism
such as repressive histone modification.30 Once type I IFN is
secreted, these two viruses are equipped with mechanism that
inhibit IFN signaling such as decreasing STAT1 phosphorylation.28 The viral proteins involved in the modulation of this
host type I IFN response are both structural proteins (such as
M, N) and non-structural proteins (ORF proteins).

ผลลัพธ์ (ไทย) 3:

Introduction